Evading pre-existing anti-hinge antibody binding by hinge engineering

The Walldius hinge arthroplasty.

Eighty-three Walldius arthroplasties, performed by one surgeon as salvage operation on the knee joint between 1966 and 1972, were independently reviewed. The fifty-seven living patients with sixty-seven arthroplasties were interviewed and examined and the clinical records of the deceased patients were inspected. Sixty-seven arthroplasties (81 per cent) were successful and sixteen failed (19 per...

Fixed hinge knee arthroplasty.

Singularities of Hinge Structures

Motivated by the hinge structure present in protein chains and other molecular conformations, we study the singularities of certain maps associated to body-andhinge and panel-and-hinge chains. These are sequentially articulated systems where two consecutive rigid pieces are connected by a hinge, i.e. a codimension two axis. The singularities correspond to a dimensional drop in the linear span o...

Structural study of hinge bending in L-arabinose-binding protein.

The L-arabinose-binding protein of Escherichia coli is a periplasmic component of the bacterial L-arabinose transport system. The three-dimensional structure of the molecule has been determined by x-ray diffraction and shown to have two globular domains and a connecting hinge. Theoretical study of the flexibility of the hinge using computer simulation showed that the hinge is quite permissive i...

Extremal Configurations of Hinge Structures

We study body-and-hinge and panel-and-hinge chains in R, with two marked points: one on the first body, the other on the last. For a general chain, the squared distance between the marked points gives a Morse-Bott function on a torus configuration space. Maximal configurations, when the distance between the two marked points reaches a global maximum, have particularly simple geometrical charact...